Table 1 Results for 49 identified EOCRC risk loci in the GECCO cohort (LD r² < 0.6)

rs12137323

1

222125528

Yes

A

-

Genotyped

0.19

0.16

1.25 (1.15–1.34)

3.68×10⁻⁶

−0.60 (0.86-0.32)

1.42×10⁻⁵

rs12794623

11

65029437

A

0.46

Imputed

0.13

0.11

1.33 (1.21–1.45)

4.41×10⁻⁶

−0.72 (1.07-0.37)

4.76×10⁻⁵

rs401763

6

27782528

C

-

Genotyped

0.11

0.10

1.44 (1.28–1.60)

4.71×10⁻⁶

−1.58 (2.03-1.13)

7.85×10⁻¹²

rs10139477

14

36444620

G

0.88

Imputed

0.28

0.24

1.22 (1.13–1.31)

6.68×10⁻⁶

−0.45 (0.70-0.19)

4.89×10⁻⁴

rs486476

11

116312926

G

0.83

Imputed

0.28

0.24

1.21 (1.13–1.30)

1.17×10⁻⁵

−0.52 (0.77-0.27)

4.38×10⁻⁵

rs200996

6

27811828

A

-

Genotyped

0.10

0.10

1.42 (1.26–1.57)

1.40×10⁻⁵

−1.54 (1.99-1.08)

2.89×10⁻¹¹

rs200948

6

27835272

C

-

Genotyped

0.10

0.10

1.41 (1.25–1.57)

1.73×10⁻⁵

−1.53 (1.98-1.07)

4.11×10⁻¹¹

rs17078858

13

85537208

T

0.75

Imputed

0.25

0.21

1.21 (1.12–1.30)

2.14×10⁻⁵

−0.48 (0.73-0.22)

2.09×10⁻⁴

rs7582080

2

76839833

A

-

Genotyped

0.28

0.24

1.20 (1.11–1.28)

2.42×10⁻⁵

−0.45 (0.69-0.20)

3.17×10⁻⁴

rs138234416

6

27992898

A

0.93

Imputed

0.09

0.08

1.50 (1.31–1.70)

3.07×10⁻⁵

−2.01 (2.55-1.46)

4.06×10⁻¹³

rs1620412

15

42308065

G

0.60

Imputed

0.27

0.23

1.20 (1.11–1.28)

3.30×10⁻⁵

−0.51 (0.75-0.26)

5.31×10⁻⁵

rs818176

2

10625156

C

0.43

Imputed

0.17

0.17

1.21 (1.12–1.29)

3.61×10⁻⁵

−0.47 (0.72-0.21)

3.57×10⁻⁴

rs200977

6

27854301

C

0.98

Imputed

0.10

0.10

1.40 (1.24–1.56)

3.98×10⁻⁵

−1.54 (2.00-1.07)

9.14×10⁻¹¹

rs17600200

8

41455004

G

-

Genotyped

0.05

0.04

1.38 (1.22–1.53)

4.43×10⁻⁵

−1.05 (1.54-0.54)

4.52×10⁻⁵

rs7071

3

122293773

T

0.45

Imputed

0.16

0.12

1.21 (1.12–1.30)

4.72×10⁻⁵

−0.57 (0.84-0.28)

9.89×10⁻⁵

rs1874629

16

84960383

A

0.83

Imputed

0.40

0.34

1.17 (1. 10⁻1.25)

4.90×10⁻⁵

−0.49 (0.70-0.26)

1.41×10⁻⁵

rs1996878

4

189600503

A

0.52

Imputed

0.03

0.03

1.41 (1.24–1.58)

5.36×10⁻⁵

−1.02 (1.55-0.47)

2.44×10⁻⁴

rs17092631

11

116476765

C

-

Genotyped

0.10

0.07

1.32 (1.19–1.46)

6.06×10⁻⁵

−0.98 (1.40-0.55)

6.43×10⁻⁶

rs34203164

20

38956548

T

0.84

Imputed

0.09

0.08

1.29 (1.17–1.42)

6.48×10⁻⁵

−0.69 (1.06-0.30)

3.64×10⁻⁴

rs10848143

12

131025190

G

0.61

Imputed

0.21

0.19

1.19 (1.10–1.27)

1.21×10⁻⁴

−0.55 (0.79-0.29)

2.13×10⁻⁵

rs9672119

14

62961239

T

0.91

Imputed

0.09

0.09

1.27 (1.15–1.39)

1.32×10⁻⁴

−0.84 (1.21-0.47)

9.26×10⁻⁶

rs17043770

2

53132960

G

-

Genotyped

0.09

0.07

1.32 (1.18–1.46)

1.34×10⁻⁴

−0.87 (1.29-0.44)

6.44×10⁻⁵

rs9602610

13

85533819

G

0.74

Imputed

0.23

0.20

1.19 (1.10–1.28)

1.40×10⁻⁴

−0.47 (0.72-0.20)

4.08×10⁻⁴

rs200965

6

27866384

A

0.97

Imputed

0.15

0.16

1.26 (1.14–1.38)

1.59×10⁻⁴

−1.12 (1.47-0.77)

2.38×10⁻¹⁰

rs1450884

7

131844887

C

0.83

Imputed

0.31

0.28

1.18 (1.09–1.26)

1.61×10⁻⁴

−0.49 (0.73-0.24)

7.33×10⁻⁵

rs10505506

8

129045291

Yes

G

-

Genotyped

0.47

0.44

1.16 (1.08–1.23)

2.01×10⁻⁴

−0.38 (0.59-0.16)

4.52×10⁻⁴

rs11594481

10

133019289

G

0.53

Imputed

0.08

0.07

1.28 (1.15–1.41)

2.20×10⁻⁴

−0.73 (1.11-0.33)

2.76×10⁻⁴

rs13197633

6

28174757

A

0.85

Imputed

0.08

0.07

1.48 (1.27–1.69)

2.23×10⁻⁴

−2.23 (2.80-1.64)

5.86×10⁻¹⁴

rs72710971

8

127091691

T

0.44

Imputed

0.03

0.02

1.48 (1.27–1.69)

2.23×10⁻⁴

−1.21 (1.87-0.54)

3.51×10⁻⁴

rs967699

8

144646890

G

0.48

Imputed

0.30

0.27

1.18 (1.09–1.27)

2.39×10⁻⁴

−0.54 (0.77-0.29)

1.44×10⁻⁵

rs818154

2

10643637

A

0.86

Imputed

0.41

0.40

1.15 (1.08–1.23)

2.45×10⁻⁴

−0.44 (0.65-0.22)

4.84×10⁻⁵

rs34409918

6

27685348

G

0.58

Imputed

0.08

0.07

1.46 (1.25–1.66)

2.48×10⁻⁴

−1.98 (2.53-1.42)

3.59×10⁻¹²

rs13197175

6

28129231

T

-

Genotyped

0.08

0.07

1.47 (1.26–1.68)

2.82×10⁻⁴

−2.23 (2.80-1.64)

5.35×10⁻¹⁴

rs818174

2

10626376

T

0.54

Imputed

0.38

0.35

1.15 (1.08–1.23)

2.83×10⁻⁴

−0.41 (0.62-0.19)

2.36×10⁻⁴

rs10218752

1

163171868

C

-

Genotyped

0.20

0.19

1.18 (1.09–1.27)

2.93×10⁻⁴

−0.48 (0.73-0.21)

3.59×10⁻⁴

rs35501037

6

27739566

A

0.85

Imputed

0.08

0.08

1.44 (1.24–1.64)

3.02×10⁻⁴

−1.98 (2.53-1.42)

2.17×10⁻¹²

rs11848737

14

62956957

C

0.91

Imputed

0.13

0.12

1.22 (1.11–1.33)

3.06×10⁻⁴

−0.63 (0.95-0.31)

1.15×10⁻⁴

rs7668968

4

66726174

G

0.59

Imputed

0.42

0.40

1.15 (1.07–1.22)

3.07×10⁻⁴

−0.44 (0.64-0.22)

5.64×10⁻⁵

rs2358662

14

54807541

Yes

C

-

Genotyped

0.25

0.24

1.16 (1.08–1.25)

3.09×10⁻⁴

−0.46 (0.70-0.22)

1.35×10⁻⁴

rs9552210

13

21067941

G

0.50

Imputed

0.49

0.46

1.16 (1.08–1.24)

3.54×10⁻⁴

−0.40 (0.62-0.17)

3.81×10⁻⁴

rs13199649

6

27868792

T

-

Genotyped

0.08

0.07

1.46 (1.25–1.67)

3.67×10⁻⁴

−2.14 (2.71-1.56)

3.87×10⁻¹³

rs431845

13

113421026

C

0.41

Imputed

0.06

0.06

1.31 (1.16–1.46)

3.68×10⁻⁴

−0.83 (1.29-0.36)

4.33×10⁻⁴

rs4675566

2

206787764

C

0.98

Imputed

0.26

0.24

1.17 (1.08–1.26)

3.69×10⁻⁴

−0.52 (0.78-0.26)

5.69×10⁻⁵

rs28510083

4

55456806

T

0.96

Imputed

0.22

0.20

1.17 (1.09–1.26)

3.99×10⁻⁴

−0.53 (0.79-0.27)

4.37×10⁻⁵

rs73149853

7

130883780

A

0.89

Imputed

0.17

0.13

1.22 (1.11–1.33)

4.16×10⁻⁴

−0.61 (0.94-0.28)

2.85×10⁻⁴

rs16974504

15

54612426

G

-

Genotyped

0.15

0.11

1.22 (1.11–1.34)

4.22×10⁻⁴

−0.66 (1.00-0.32)

1.32×10⁻⁴

rs10958911

9

10135016

A

0.47

Imputed

0.13

0.11

1.21 (1.11–1.32)

4.26×10⁻⁴

−0.59 (0.91-0.26)

3.88×10⁻⁴

rs187956

1

77508652

G

0.82

Imputed

0.35

0.32

1.15 (1.07–1.23)

4.58×10⁻⁴

−0.45 (0.67-0.22)

1.05×10⁻⁴

rs35702572

14

63087698

C

0.52

Imputed

0.28

0.24

1.16 (1.08–1.25)

4.90×10⁻⁴

−0.48 (0.72-0.23)

1.16×10⁻⁴