Table 1 Cox-regression analysis of survival outcomes in the 69 cases screened with TMZ in vitro

Age

(<50 years, n = 13) vs. (≥50 years, n = 56)

0.803

0.425–1.52

0.500

0.857

0.451–1.63

0.638

Gender

Male (n = 34) vs. Female (n = 35)

1.11

0.671–1.84

0.681

0.881

0.524–1.49

0.636

MGMT promoter methylation

UM (n = 35) vs. M (n = 33)

2.26

1.32–3.88

0.003

1.71

0.973–3.00

0.0622

1.708

0.992–2.94

0.0535

Extent of resection

GTR (n = 35) vs. STR (n = 29)

1.97

1.18–3.30

9.56e−3

2.00

1.19–3.38

9.10e−3

1.722

1.02–2.92

0.0432

2.02

1.17–3.49

0.0114

In vitro TMZ sensitivity

Resistant (n = 29) vs. Sensitive (n = 40)

2.75

1.55–4.91

5.71e−4

2.45

1.33–4.52

4.06e−3

2.537

1.45–4.45

1.18e−3

2.90

1.61–5.19

3.6e−4