X chromosome dosage and the genetic impact across human tissues

Table 1 Up- and downregulated differentially expressed genes

		45,X vs 46,XX		45,X vs 46,XY		47,XXY vs 46,XX		47,XXY vs 46,XY
		Up	Down	Up	Down	Up	Down	Up	Down
Blood	X chromosome	54	91	60	48	15	7	40	4
Blood	Autosomes	1409	1244	1763	739	216	188	149	64
Fat	X chromosome	0	30	43	60	85	75	38	4
Fat	Autosomes	47	113	1885	1656	2484	2715	239	118
Muscle	X chromosome	2	18	46	67	50	33	29	4
Muscle	Autosomes	20	22	2148	1770	1499	1549	120	74

Number of differentially expressed genes (adjusted p-value < 0.05, FDR < 0.05) both up- (log2FC > 0) and downregulated (log2FC < 0) in blood, fat, and muscle tissue in all four contrasts; 45,X vs. 46,XX, 45,X vs. 46,XY, 47,XXY vs. 46,XX, and 47,XXY vs. 46,XY. The bold font indicates if the majority of differentially expressed genes were either up- or downregulated in the given contrast

ISSN: 1756-994X