X chromosome dosage and the genetic impact across human tissues

Table 2 Overlapping differentially expressed X chromosomal genes in blood, fat and muscle

HGNC gene symbol	Location on X chromosome	XCI status	Function
JPX	XIC	Escape	Participate in X chromosome inactivation
TSIX	XIC	Variable escape	Participate in X chromosome inactivation
XIST	XIC	Mostly subjected to inactivation	Participate in X chromosome inactivation
AKAP17A	PAR 1 region	Escape	Regulatory genomic functions: Splicing
CD99	PAR 1 region	Escape	Involved in cell adhesion, migration, death, differentiation and diapedesis
DHRSX	PAR 1 region	Escape	Involved in regulation of autophagy
GTPBP6	PAR 1 region	Escape	Regulatory genomic functions: Translation
PPP2R3B	PAR 1 region	Escape	Involved in the regulation of cell growth and division
SLC25A6	PAR 1 region	Escape	Transporter activity and ATP:ADP antiporter activity
ZBED1	PAR 1 region	Escape	Regulatory genomic functions: Transcription
EIF2S3	Xp22.11	Escape	Regulatory genomic functions: Translation
KDM6A	Xp11.3	Escape	Regulatory genomic functions: Ubiquitination and chromatin modification
PUDP	Xp22.31	Escape	Unknown
ZFX	Xp22.11	Escape	Regulatory genomic functions: Transcription

Differentially expressed X chromosomal genes (adjusted p-value < 0.05 and FDR < 0.05) in all three tissues; blood, fat, and muscle. Table describes the location of the gene on the X chromosome, XCI (X chromosomal inactivation) status as escape, variable escape, inactive, and known function of the gene

ISSN: 1756-994X