X chromosome dosage and the genetic impact across human tissues

Table 3 Hyper- and hypomethylated positions

		45,X vs 46,XX		45,X vs 46,XY		47,XXY vs 46,XX		47,XXY vs 46,XY
		Hyper	Hypo	Hyper	Hypo	Hyper	Hypo	Hyper	Hypo
Blood	X chromosome	2160	6798	4	94	1	4	5825	2924
Blood	Autosomes	228	820	222	696	151	42	287	71
Fat	X chromosome	3063	4502	1692	2	4	12	5207	2261
Fat	Autosomes	70	201	1073	160	101	552	126	49
Muscle	X chromosome	3521	4389	2698	2	2	17	5041	2773
Muscle	Autosomes	316	92	6909	132	102	4256	54	88

Number of differentially hyper- and hypomethylated positions in blood, fat, and muscle tissue, across all four contrasts; 45,X vs. 46,XX, 45,X vs. 46,XY, 47,XXY vs. 46,XX, and 47,XXY vs. 46,XY. The bold font indicates if the majority of positions were either hyper- or hypomethylated in the given contrast

ISSN: 1756-994X