Fig. 2
From: Stalled oligodendrocyte differentiation in IDH-mutant gliomas
Suppressed myelination program in PM gliomas from the CGGA dataset. A Under expression in PM gliomas of the MO marker GALC/O1, myelin components (MBP, MOG), and myelination regulators MYRF/C11ORF9. B Sustained expression of stage-specific markers of pre-OPC and OPC in PM gliomas. C Sustained expression of stage-specific marker of NFOL in PM gliomas. D Co-staining with LFB which labels myelin structures, and with the anti-IDH1 R132H antibody which stains IDH1 mutant cells, of a representative PM glioma with 1p19q co-deletion is shown for tumor (left) and NT (right) regions. Myelin fiber is absent in tumor regions with strong cytosolic staining of the IDH1 R132H mutant protein