Fig. 8
From: Stalled oligodendrocyte differentiation in IDH-mutant gliomas
Schematic depiction of differentiation blockage of IDH-mutant gliomas. A, B IDH-mutant astrocytomas and oligodendrogliomas are both blocked at the premyelination stage due to hypermethylation and down-regulated expression of myelination regulators and myelin components. OPC: oligodendrocyte progenitor cell, OLs: oligodendrocytes