Molecular characteristics of breast tumors in patients screened for germline predisposition from a population-based observational study

Table 2 Swedish Breast Cancer Group criteria for screening for variants in predisposition genes as implemented in 2017 and how many patients meet those criteria in SCAN-B. Criteria from before 2017 are available in [32]

Criteria	SCAN-B cases^b
Breast cancer ≤ 40 years of age	329
Breast cancer ≤ 50 years of age if there is at least one other case of breast cancer in first-degree or second-degree relatives^a	NA
Breast cancer ≤ 60 years of age if there are at least two other cases of breast cancer in first-degree or second-degree relatives^a	NA
Triple-negative breast cancer ≤ 60 years of age	298
Male breast cancer irrespective of age	48
Ovarian cancer including fallopian tube cancer and primary peritoneal carcinomatosis (not mucinous nor borderline) irrespective of age	NA
Meeting criteria for other hereditary syndromes that include breast/ovarian cancer	NA

^a The other cancer cases can also be of ovarian cancer, early prostate cancer (before the age of 65), or pancreatic cancer. Bilateral breast cancer counts as two cases.
^b NA number of patients could not be calculated since family history was not accessible to the study

ISSN: 1756-994X