Fig. 2

Gene alteration rates in baseline ctDNA are not different between clonal vs subclonal multiple PIK3CAmut. Tile plots from FoundationOne^®Liquid (F1L) sequencing of baseline ctDNA from SANDPIPER participants exhibit the somatic alterations co-occurrent with samples categorized as (A) clonal multiple PIK3CAmut or (B) subclonal multiple PIK3CAmut. Samples are represented in the columns, whereas genes are represented in the rows. No statistically significant difference was observed in the individual gene alteration rates between these PIK3CAmut clonality subgroups (p-value > 0.05; Fisher’s Exact Test). Orange boxes represent samples with multiple alteration types identified in one gene