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Fig. 7 | Genome Medicine

Fig. 7

From: Genomic and transcriptomic features between primary and paired metastatic fumarate hydratase–deficient renal cell carcinoma

Fig. 7

Methylation phenotype and heterogeneity between primary and metastatic lesions. A T-distributed stochastic neighbor embedding (TSNE) analysis. Data of FH-RCC included in the present study and TCGA-pan RCC cohort were both integrated into TSNE map. B Differentially methylated probes identified between paired metastatic and primary FH-RCC. C Enrichment analysis of hypomethylated probes in metastatic lesions (compared to the paired primary lesions). D Heatmap of methylation levels of chemokine-related and immune checkpoint-related genes in paired normal, primary, and metastatic lesions. E Box plots depict the difference in of hypomethylation degree among normal, primary, and metastatic lesions of FH-RCC. P-value was determined by the Kruskal-Wallis test and Dunn’s test

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Genome Medicine

ISSN: 1756-994X

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