Table 2 LD-independent loci associated with hearing problems reaching genome-wide significance (p < 5 × 10−8) in the meta-analysis of UK Biobank (UKB), Nurses’ Health Studies (NHS; I and II), and Health Professional Follow-up Study (HPFS). The results of the replication analysis in Million Veteran Program (MVP) are also reported. Abbreviations: CHR chromosome, POS position, bp base pairs, EAF effect allele frequency, OR odds ratio, P P-value
From: Sex differences in the polygenic architecture of hearing problems in adults
rsID | CHR | POS (bp) | Effect allele | Other allele | UKB-NHS-HPFS meta-analysis | MVP replication | ||
|---|---|---|---|---|---|---|---|---|
OR | P | OR | P | |||||
rs11073804 | 15 | 89,252,012 | A | T | 0.95 | 5.60 × 10−17 | 0.91 | 3.50 × 10−28 |
rs9493627 | 6 | 133,789,728 | A | G | 1.04 | 1.03 × 10−17 | 1.06 | 1.91 × 10−19 |
rs10901863 | 10 | 126,812,270 | T | C | 1.05 | 6.21 × 10−23 | 1.06 | 1.17 × 10−11 |
rs1566128 | 14 | 52,514,981 | A | G | 1.04 | 1.02 × 10−15 | 1.04 | 3.98 × 10−11 |
rs2254303 | 6 | 43,276,390 | A | G | 1.05 | 1.19 × 10−23 | 1.04 | 5.23 × 10−11 |
rs143282422 | 10 | 73,377,112 | A | G | 1.16 | 4.43 × 10−11 | 1.22 | 8.30 × 10−11 |
rs7819550 | 8 | 74,206,582 | A | G | 1.04 | 6.96 × 10−10 | 1.05 | 3.92 × 10−9 |
rs6662164 | 1 | 46,146,230 | A | T | 1.04 | 6.59 × 10−17 | 1.04 | 7.44 × 10−9 |
rs6871548 | 5 | 73,076,024 | T | C | 1.05 | 2.30 × 10−25 | 1.04 | 1.23 × 10−8 |
rs6545432 | 2 | 54,817,683 | A | G | 1.04 | 1.05 × 10−15 | 1.04 | 2.37 × 10−8 |
rs739138 | 22 | 38,122,462 | A | G | 0.95 | 4.70 × 10−19 | 0.96 | 6.21 × 10−8 |
rs67307131 | 11 | 118,480,223 | T | C | 0.96 | 3.12 × 10−18 | 0.97 | 2.83 × 10−7 |
rs36062310 | 22 | 50,988,105 | A | G | 1.15 | 2.75 × 10−32 | 1.08 | 4.80 × 10−6 |
rs11238325 | 7 | 50,853,151 | T | C | 1.04 | 1.88 × 10−11 | 1.04 | 5.65 × 10−6 |
rs11022697 | 11 | 13,178,285 | C | G | 0.97 | 1.17 × 10−9 | 0.97 | 1.15 × 10−5 |
rs7712395 | 5 | 2,559,538 | T | C | 1.05 | 3.64 × 10−11 | 1.04 | 6.45 × 10−5 |
rs6675438 | 1 | 165,112,224 | A | T | 1.03 | 8.82 × 10−11 | 1.03 | 1.62 × 10−4 |
rs2296506 | 6 | 158,507,981 | A | G | 1.03 | 1.70 × 10−13 | 1.02 | 3.36 × 10−4 |
rs2877561 | 3 | 121,712,051 | A | C | 1.04 | 1.62 × 10−14 | 1.03 | 4.95 × 10−4 |
rs12156228 | 8 | 141,701,299 | T | G | 0.97 | 3.67 × 10−12 | 0.97 | 6.31 × 10−4 |
rs222836 | 17 | 7,133,162 | A | G | 0.97 | 1.13 × 10−11 | 0.98 | 7.37 × 10−4 |
rs11085064 | 19 | 4,209,152 | A | G | 1.04 | 2.84 × 10−9 | 1.03 | 9.49 × 10−4 |
rs57167368 | 10 | 80,521,351 | A | G | 0.96 | 9.91 × 10−11 | 0.97 | 0.001 |
rs72622588 | 3 | 182,003,490 | T | G | 0.95 | 1.53 × 10−16 | 0.97 | 0.002 |
rs58919600 | 5 | 92,970,519 | T | C | 1.04 | 1.86 × 10−9 | 1.03 | 0.002 |
rs13171669 | 5 | 148,601,243 | A | G | 0.97 | 1.15 × 10−12 | 0.98 | 0.007 |
rs73204028 | 7 | 115,092,852 | T | C | 0.97 | 2.20 × 10−8 | 0.98 | 0.012 |
rs5800853 | 12 | 109,790,748 | CAG | C | 1.03 | 4.87 × 10−9 | 1.02 | 0.017 |
rs1171114 | 6 | 84,227,646 | T | C | 0.97 | 2.69 × 10−10 | 0.98 | 0.018 |
rs35094336 | 8 | 82,670,771 | A | G | 1.06 | 2.07 × 10−11 | 1.03 | 0.021 |
rs72930998 | 18 | 52,632,968 | T | C | 0.97 | 2.03 × 10−10 | 0.98 | 0.028 |
rs1928176 | 6 | 21,968,899 | A | G | 0.97 | 5.44 × 10−9 | 0.99 | 0.028 |
rs61734651 | 20 | 61,451,332 | T | C | 1.06 | 1.30 × 10−8 | 1.03 | 0.028 |
rs9530470 | 13 | 76,416,638 | A | G | 0.97 | 5.64 × 10−9 | 0.99 | 0.051 |
rs11041717 | 11 | 8,054,933 | A | C | 0.96 | 7.31 × 10−15 | 0.98 | 0.071 |
rs717973 | 2 | 208,091,112 | A | G | 0.97 | 4.61 × 10−10 | 0.99 | 0.072 |
rs8063057 | 16 | 53,812,433 | T | C | 1.03 | 1.64 × 10−8 | 1.01 | 0.081 |
rs2354376 | 7 | 138,487,145 | A | C | 1.03 | 3.17 × 10−10 | 1.01 | 0.1 |
rs78229182 | 6 | 151,128,784 | T | C | 1.05 | 2.07 × 10−8 | 0.98 | 0.106 |
rs148512269 | 2 | 227,596,034 | T | G | 1.11 | 9.83 × 10−9 | 1.05 | 0.133 |
rs72818515 | 10 | 76,060,718 | A | C | 1.03 | 7.08 × 10−10 | 1.01 | 0.186 |
rs111935448 | 16 | 30,919,807 | T | C | 1.04 | 1.75 × 10−9 | 0.99 | 0.218 |
rs35624969 | 7 | 72,991,592 | T | C | 0.97 | 4.66 × 10−8 | 0.99 | 0.218 |
rs4948502 | 10 | 63,839,417 | T | C | 1.03 | 1.26 × 10−11 | 1.01 | 0.229 |
rs566673 | 11 | 66,401,373 | T | G | 0.97 | 1.80 × 10−8 | 1.01 | 0.277 |
rs34073570 | 5 | 103,998,895 | CT | C | 0.97 | 1.32 × 10−9 | 0.99 | 0.316 |
rs112725535 | 1 | 6,494,086 | A | G | 0.96 | 7.85 × 10−10 | 0.99 | 0.318 |
rs2273654 | 10 | 102,689,217 | T | C | 0.97 | 4.01 × 10−8 | 0.99 | 0.425 |
rs8102051 | 19 | 2,370,476 | A | C | 1.03 | 3.38 × 10−9 | 1.01 | 0.429 |
rs13147559 | 4 | 17,524,570 | C | G | 0.95 | 3.81 × 10−14 | 0.99 | 0.596 |
rs61863078 | 10 | 94,777,108 | A | G | 1.03 | 1.54 × 10−9 | 1 | 0.777 |
rs766262445 (MVP LD-proxy: rs9536378) | 13 | 53,830,039 | CT(A) | C | 1.03 | 2.63 × 10−8 | 1 | 0.787 |
rs34993346 | 11 | 89,046,097 | A | G | 0.95 | 1.38 × 10−24 | 1 | 0.872 |
rs9783279 | 11 | 68,972,992 | A | C | 0.97 | 2.97 × 10−9 | 1 | 0.872 |