Fig. 3

Expression patterns of GPR68 and GRID2 across cell types in human dorsal root ganglia (DRG) [35]. The y-axis represents counts per million (CPM) (top) and log(CPM) (bottom) of the pseudo-bulk expression of genes in the annotated cell types in the human DRG from n = 5 donors. DRG neurons are designated in green whereas non-neuronal cells are shown in orange. DRG neurons are molecularly classified into different groups: heavily myelinated limb proprioceptors and A-fiber low-threshold mechanoreceptors (LTMRs) that process innocuous touch sensation and proprioception; C-fiber non-peptidergic (NP) nociceptors that process nociception and pruritus; non-myelinated C-fiber and lightly myelinated A-fiber peptidergic (PEP) nociceptors which process inflammatory heat-induced and sharp pinprick nociception; cold thermoreceptors which are A-fiber and C-fiber nociceptors that process cold sensation