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Table 1 Cohort characteristics. Per trial arm characteristics are provided in Additional file 1: Table S1

From: Whole genome sequencing across clinical trials identifies rare coding variants in GPR68 associated with chemotherapy-induced peripheral neuropathy

Characteristics

Entire cohort

Taxane-treated

Non-taxane

N = 4900

N = 2535

N = 2365

Age

 > 65

2150

1012

1138

 ≤ 65

2750

1523

1227

Sex

 Male

2746

1068

1678

 Female

2154

1467

687

Prior chemotherapy

 Naive

4240

2368

1872

 Excluding taxanes

167

167

0

 Any

493

0

493

BSA m2 median [quartiles]

1.84 [1.69–1.98]

1.81[1.67–1.96]

1.88 [1.73–2.03]

Prev. diabetes diagnosis

743

362

381

Chemotherapy received

 Taxane and platinum

2035

2035

0

 Platinum only

626

0

626

 Taxane only

500

500

0

 None

1739

0

1739

PN events

1117

1002

115

 Grade 1

709

634

75

 Grade  ≥ 2

408

368

40