Fig. 2

Transcriptomic analyses of SCZ and CON cortical neurons. A Heatmap of the top 50 DEGs for seven CON and seven SCZ neurons. B GO analysis showing the top 20 categories in molecular function, localization and processes. C,D Network map of genes upregulated and downregulated genes in SCZ generated using STRING software. PPI enrichment p-value < 1.0e − 16 for both networks. Each node represents all proteins produced by a single, protein-coding gene locus. Red colored nodes are query proteins and first shell of interactors. Green nodes indicate secondary interactions. Blue nodes represent tertiary interactions. Edges represent protein–protein associations indicating that proteins jointly contribute to a shared function, though they do not necessarily interact with each other physically. Line thickness is proportional to edge confidence