Skip to main content
Fig. 1 | Genome Medicine

Fig. 1

From: Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy

Fig. 1

Single-cell RNA-seq reveals reductions in nonclassical monocytes in MAPT pathogenic variant carriers. A Two-dimensional UMAP plot of ~ 181,000 PBMCs from MAPT variant carriers and non-carrier controls, colored by cluster identity. Major cell types are labeled within the plot. B, C Cluster 11, marked by high FCGR3A expression and identified as NC monocytes, was significantly reduced in MAPT carriers (p = 0.02; data are expressed as percentage of total PBMCs for each sample). D Myeloid cells (clusters 2, 11, 14) were subset and re-clustered. NC monocyte and cDC2 subclusters were identified by FCGR3A and CLEC10A expression, respectively (D, right). E The ratio of NC monocytes to cDC2 was significantly reduced in MAPT variant carriers (p = 0.01)

Back to article page

Genome Medicine

ISSN: 1756-994X

Contact us