Fig. 2
Differential expression in MAPT variant carriers by cell cluster. A Clusters are grouped by cell type and ranked by the number of DEGs with pFDR < 0.05 and absolute LFC > 0.2. Differential expression was determined in MAPT variant carriers relative to non-carrier controls while covarying for age, sex, and scRNA-seq batch. Solid-colored portions of the bars indicate DEGs shared by at least one other cluster, while the translucent portions indicate DEGs unique to a given cluster. cDCs (cluster 14), NK cells (clusters 3 and 15), and NC monocytes (cluster 11) had the highest numbers of DEGs with absolute LFC > 0.2. B Volcano plots of the NC monocyte cluster and major NK cell cluster; DEGs with absolute LFC > 0.2 are labeled in blue (downregulated) or red (upregulated). Several NK cell DEGs (right) with − log10(pFDR) values > 300 were set to 300 for visualization purposes