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Fig. 4 | Genome Medicine

Fig. 4

From: Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy

Fig. 4

CX3CR1 expression is reduced in peripheral myeloid and lymphoid cells in familial tauopathy. A CX3CR1 is robustly expressed in both NC monocytes (cluster 11) and NK cells (cluster 3). NC monocytes (B; pFDR = 5.6 × 10−46) and NK cells (C; pFDR = 2.6 × 10−120) both show significantly reduced expression of CX3CR1 in MAPT pathogenic variant carriers. D Reanalysis of publicly available bulk RNA-seq data from mouse hippocampal CD11b+ microglia demonstrated a significant reduction (pFDR = 2.5 × 10−7) of Cx3cr1 in the MAPT P301S model

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Genome Medicine

ISSN: 1756-994X

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