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Fig. 5 | Genome Medicine

Fig. 5

From: Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy

Fig. 5

Confirmation of reduced CX3CR1 expression in MAPT variant carrier PBMCs via ddPCR. RNA was isolated from PBMCs from MAPT variant carriers and healthy, non-carrier controls; gene expression was determined by RT-ddPCR. A CX3CR1 was significantly reduced in MAPT carrier PBMCs (p = 0.0007) relative to controls. B Separation of samples according to MAPT variant class (non-splicing and splicing) reveals that CX3CR1 was significantly reduced in both groups, relative to controls (non-splicing, p = 0.01; splicing, p = 0.003)

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Genome Medicine

ISSN: 1756-994X

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