Fig. 6
Analysis of nonclassical monocyte marker genes in MAPT variant carriers. A FCGR3A, the NC monocyte marker gene encoding CD16, is robustly expressed not only in NC monocytes but also in NK cells. FCGR3A is significantly reduced in both NC monocytes (left; pFDR = 5.3 × 10−45) and NK cells (right; pFDR = 3.0 × 10−182) in MAPT pathogenic variant carriers. B ddPCR confirmed a reduction in FCGR3A reduction in MAPT variant carrier PBMCs (p = 0.01). C Additional genes expressed specifically (VMO1, left) or enriched in (IFITM3, right) NC monocytes showed significant alterations (D) in MAPT variant carrier NC monocytes. D VMO1 (left) was significantly reduced (pFDR = 9.2 × 10−16), while IFITM3 (right) was significantly increased (pFDR = 4.9 × 10−29) in MAPT carriers