Fig. 7
Analysis of TMEM176A/B in MAPT pathogenic variant carriers. A TMEM176A/B are highly expressed in both classical (cluster 2) and NC (cluster 11) monocytes. B TMEM176A/B are significantly reduced in NC monocytes (TMEM176A, pFDR = 2.4 × 10−31; TMEM176B, pFDR = 2.7 × 10.−105) from MAPT carriers. These genes were similarly reduced in MAPT carrier classical monocytes (cluster 2; Additional file 5: Table S4). The reduction in TMEM176A (C) and TMEM176B (D) in MAPT variant carriers was confirmed using bulk PBMC RNA and ddPCR (TMEM176A, p = 0.03; TMEM176B, p = 0.02)