Table 1 Demographic characteristics of cohort

n

8

8

Age, mean (SD)

52.8 (10.0)

54.4 (11.4)

Sex, n female

4

4

Clinical syndrome (n)

Clinically normal (8)

bvFTD (4), frontal AD (1), subjective cognitive impairment (1), presymp. (2)

MAPT variants (n)

N/A

p.P301L (1), p.S305I (1), p.S305S (1), p.R406W (3), IVS10 + 16 (2)

Splicing variants, n

N/A

4

CDR-SB, mean (SD)

0.0 (0.0)

5.8 (5.7)

7.8 (5.3)^#