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Table 1 All admixture mapping results by ancestry and super pathway in independent local ancestry regions

From: Ancestry-driven metabolite variation provides insights into disease states in admixed populations

 

Significant LA regions

Driving ancestry from ancestry-specific analysis

Super pathway

Chr

Metabolites

n

Novel

n (%)

Total

n

NAM

n (%)

AFR

n (%)

EUR

n (%)

Lipids

n (%)

Amino acids

n (%)

Other

n (%)

2

13

41 (48)

85

-

78 (92)

7 (8)

1 (8)

11 (85)

1 (7)

4

1

-

1

-

1 (100)

-

1 (100)

-

-

5

3

14 (74)

19

14 (74)

3 (16)

2 (11)

-

2 (67)

1 (33)

6

1

-

1

1 (100)

-

-

-

-

1 (100)

8

4

8 (53)

15

1 (7)

5 (33)

9 (60)

-

4 (100)

-

9

1

-

1

-

1 (100)

-

-

-

1 (100)

10

2

13 (65)

20

3 (15)

-

17 (85)

1 (50)

-

1 (50)

11

38

114 (70)

164

263 (99.6)

1 (0.4)

-

37 (97)

1 (3)

-

12

4

7 (58)

12

6 (50)

6 (50)

-

2 (50)

2 (50)

-

13

1

-

1

-

1 (100)

-

-

-

1 (100)

15

8

15 (58)

26

14 (54)

-

12 (46)

6 (75)

2 (25)

-

16

4

20 (51)

39

6 (15)

33 (85)

-

-

3 (75)

1 (25)

  1. Novel regions are local ancestry regions containing no significant SNVs from GWAS. The total number of significant local ancestry regions allows for duplicate significant regions across metabolites for the corresponding chromosome. Ancestry-specific analysis was performed on all metabolites significant in joint (all-ancestries) admixture mapping. The driving ancestry was the ancestry group with the smallest p-value in ancestry-specific testing. Metabolic super pathways represent overall metabolite function in the body
  2. Chr chromosome, LA local ancestry, NAM Native American driving ancestry, AFR African driving ancestry, EUR European driving ancestry