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Fig. 2 | Genome Medicine

Fig. 2

From: Prioritizing genes associated with brain disorders by leveraging enhancer-promoter interactions in diverse neural cells and tissues

Fig. 2

Reliability of the reconstructed EPIs. a Histogram showing the number of genes that were predicted as linked with a range number of enhancers. b Histogram showing the distribution of distance between the enhancers to their target promoters for the reconstructed EPIs. c Odds ratio enrichment of cis-eQTL and cis-sQTL variants [34] in the promoter-linked enhancers and enhancer-linked promoters, respectively. *** P < 0.001; Wilcoxon test. d The accuracy of different EPI prediction approaches. We estimated the accuracy of the reconstructed EPIs using Area Under the Precision-Recall (AUPR) based on the pcHi-C data from 24 matching and related cell and tissues from the FANTOM5 project (Table S3). e Boxplots showing the CAGE activity and specificity of the promoters linked or not linked to enhancers. f Boxplots showing the CAGE activity and specificity of the promoters linked to a range number of enhancers. *** P < 0.001; Wilcoxon test in e and f

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Genome Medicine

ISSN: 1756-994X

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