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Fig. 4 | Genome Medicine

Fig. 4

From: Prioritizing genes associated with brain disorders by leveraging enhancer-promoter interactions in diverse neural cells and tissues

Fig. 4

Partitioned heritability enrichment of CREs from different brain cell and tissue types across diverse brain disorders and behavioral-cognitive phenotypes. a Heatmap showing the partitioned heritability enrichment of genetic variants overlapping CREs from brain cell types across different brain disorders and behavioral-cognitive phenotypes. The normalized partitioned heritability enrichment scores under the significance level of 5% were labeled with “ × ”. b Histogram showing the partitioned heritability enrichment of genetic variants overlapping CREs from adult and newborn brain tissues across different brain disorders and behavioral-cognitive phenotypes. The red dashes line indicates the FDR at the significance level of 5%. AD, Alzheimer’s disease; ADHD, attention deficit hyperactivity disorder; ALS, amyotrophic lateral sclerosis; ASD, autism spectrum disorder; AUD, alcohol use disorder; BIP, bipolar disorder; MS, multiple sclerosis; OCD, obsessive–compulsive disorder; PD, Parkinson’s disease; SCZ, Schizophrenia; TS, Tourette’s syndrome

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Genome Medicine

ISSN: 1756-994X

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