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Fig. 3 | Genome Medicine

Fig. 3

From: A meta-analysis of immune-cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes

Fig. 3

Non-linear rate of change of immune-cell-type fractions with age. a Left panel: Smoothed density scatterplot of the estimated naïve CD8 + T-cell fraction against chronological age for all samples aged between 20 and 85 from 20 cohorts, with the loess regression curve (span = 0.3) displayed in magenta. Excluded cohorts are MRC1946, which only contains samples of the same age (age = 53) and Song, which profiled PBMCs and not whole blood. Middle and Right panels: as left but plotting males and females separately. b As a but for the estimated naïve CD4 + T-cell fraction. Only samples aged between 20 and 85 from 16 cohorts where the association of naïve CD4 + fraction with age was significant (multivariate linear regression P < 0.05) and with same directionality were used. Excluded cohorts are MRC1946, Hannum, Tsaprouni, HPT-450 k, Song, and VACS

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Genome Medicine

ISSN: 1756-994X

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