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Fig. 1 | Genome Medicine

Fig. 1

From: Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis

Fig. 1

Conditional Q-Q plots of nominal –log10 p-values vs empirical –log10 p-values in irritable bowel syndrome (IBS) below the standard genome-wide association study threshold of p < 5.0 × 10−8 as a function of significance of association with generalized anxiety disorder (GAD), major depression (MD), bipolar disorder (BIP), schizophrenia (SCZ), diverticular disease (DVD), or inflammatory bowel disease (IBD) below the level of –log10 p-values of 1, 2, or 3, corresponding to p < 0.10, p < 0.01 and p < 0.001, respectively. The blue line includes all SNPs and dashed lines indicate the null hypothesis

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Genome Medicine

ISSN: 1756-994X

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