Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis

Table 1 List of genome-wide association study data used

Trait/phenotype	Analysis	Number of cases	Number of controls	Ancestry of participants	Source of data
Psychiatric
SCZ	MiXeR and cFDR	53,386	77,258	European	PGC-SCZ [35]
BIP	MiXeR	41,917	371,549	European	PGC-BIP + UKBB [34]
BIP	cFDR	40,463	313,436	European	PGC-BIP [34] PGC-MD + 23andMe + UKBB [30]
MD	MiXeR	246,363	561,190	European	PGC-BIP [34] PGC-MD + 23andMe + UKBB [30]
MD	cFDR	121,198	329,421	European	PGC-MD + 23andMe [31]
GAD	MiXeR and cFDR	175,163	Not applicable	European	MVP [29]
IBS	MiXeR and cFDR	53,400	433,201	European	UKBB + BGI [11]
IBS-C	cFDR	5406	72,356	European	UKBB [11]
IBS-D	cFDR	8756	72,356	European	UKBB [11]
IBS-M	cFDR	17,216	72,356	European	UKBB [11]
Somatic
IBD	MiXeR & cFDR	25,042	34,915	European	IIBDGC-IBD [38]
DVD	cFDR	17,851	14,357	European	FinnGen [36]
DVD	MiXeR	27,444	382,284	European	UKBB [37]
Height	MiXeR	709,706	Not applicable	European	GIANT + UKBB [39]

MiXeR bivariate causal mixture analyses, cFDR conditional false discovery rate analyses, PGC Psychiatric Genomics Consortium, SCZ schizophrenia, BIP bipolar disorder, MD major depression, GAD generalized anxiety disorder, IBS irritable bowel syndrome, IBS-C constipation-predominant IBS, IBS-D diarrhea-predominant IBS, IBS-M IBS with mixed constipation and diarrhea MVP Million Veterans Program, UKBB UK Biobank, BGI Belly Genes Initiative, IIBDGC International Inflammatory Bowel Disease Genetics Consortium, IBD inflammatory bowel disease, DVD diverticular disease, FinnGen Finnish biobank project, GIANT Genetic Investigation of Anthropometric Traits Consortium

ISSN: 1756-994X