Table 2 ConjFDR analyses results of shared loci associated with irritable bowel syndrome (IBS), generalized anxiety disorder (GAD), major depression (MD), bipolar disorder (BIP), schizophrenia (SCZ), diverticular disease (DVD), and inflammatory bowel disease (IBD) (FDR < 0.05)
Locus | SNP | CHR | A1/A2 | Mapped gene in OpenTargets | Function | ConjFDR IBS and GAD | ConjFDR IBS and MD | ConjFDR IBS and BIP | ConjFDR IBS and SCZ | ConjFDR IBS and DVD | ConjFDR IBS and IBD | P-value in IBS GWAS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | rs5174 | 1 | T/C | LRP8 | Exonic | 7.20E − 01 | 4.74E − 01 | 9.73E − 03 | 8.33E − 02 | 8.70E − 01 | 8.70E − 01 | 3.36E − 06 |
4a | rs4846898 | 1 | A/G | GALNT2 | Intronic | 6.73E − 02 | 4.91E − 02 | 8.45E − 01 | 7.98E − 02 | 8.98E − 01 | 2.35E − 01 | 2.60E − 04 |
4a | rs552025051 | 1 | T/TA | GALNT2 | Intronic | 1.82E − 02 | NA | NA | NA | NA | NA | 5.73E − 05 |
7a | rs2731562 | 2 | A/C | ARHGAP15 | Intronic | 7.23E − 01 | 1.00E + 00 | 7.55E − 01 | 6.95E − 01 | 2.56E − 03 | 8.65E − 01 | 3.66E − 06 |
8a | rs197261 | 2 | A/G | TANK | Downstream | 4.10E − 01 | 1.47E − 02 | 8.08E − 02 | 8.56E − 01 | 9.32E − 01 | 9.17E − 01 | 1.05E − 05 |
11 | rs9816652 | 3 | A/G | CADM2 | Intronic | 1.00E + 00 | 8.84E − 01 | 4.84E − 03 | 7.18E − 01 | 9.63E − 01 | 8.34E − 01 | 8.61E − 06 |
12a | rs147538844 | 3 | T/TC | PPP2R3A | Intergenic | 4.53E − 02 | NA | 9.22E − 01 | NA | 7.92E − 01 | NA | 8.36E − 05 |
12a | rs9871437 | 3 | A/G | PPP2R3A | Intergenic | 8.17E − 02 | 8.04E − 01 | 1.00E + 00 | 2.39E − 02 | 9.01E − 01 | 8.64E − 01 | 4.05E − 05 |
14a | rs9855202 | 3 | A/G | P2RY14 | Intronic | 1.00E + 00 | 9.79E − 01 | 8.04E − 01 | 9.67E − 01 | 1.08E − 03 | 8.50E − 01 | 1.46E − 06 |
15 | rs10014468 | 4 | A/G | IL21 | Intergenic | 3.79E − 01 | 6.04E − 03 | 9.58E − 03 | 2.83E − 02 | 1.00E + 00 | 8.47E − 01 | 2.21E − 05 |
15 | rs45510091 | 4 | A/G | KIAA1109 | Intronic | 2.26E − 01 | 7.41E − 03 | 1.17E − 02 | 1.89E − 02 | 9.98E − 01 | 8.29E − 01 | 2.97E − 05 |
16a | rs4362911 | 5 | T/G | ADCY2 | Intergenic | 7.82E − 01 | 5.49E − 01 | 8.56E − 01 | 6.16E − 03 | 9.05E − 01 | 1.00E + 00 | 7.20E − 06 |
17a | rs4388243 | 5 | A/G | PWWP2A | Intronic | 4.11E − 02 | 5.75E − 01 | 1.00E + 00 | 7.76E − 01 | 9.10E − 01 | 1.00E + 00 | 9.29E − 05 |
20a | rs2140619 | 7 | A/G | FOXP2 | Intronic | 9.25E − 03 | 9.04E − 01 | 9.71E − 01 | 9.19E − 01 | 9.13E − 01 | 1.00E + 00 | 1.57E − 05 |
21a | rs4726813 | 7 | A/G | CNTNAP2 | Intronic | 7.78E − 01 | 3.35E − 01 | 1.95E − 02 | 6.58E − 01 | NA | NA | 4.53E − 05 |
22a | rs898797 | 8 | T/C | MFHAS1 | ncRNA_intronic | 9.08E − 01 | 8.53E − 01 | 3.95E − 02 | 4.59E − 01 | 9.01E − 01 | 9.85E − 01 | 1.67E − 04 |
23a | rs13263876 | 8 | A/G | TCIM | ncRNA_intronic | 9.34E − 01 | 5.91E − 01 | 7.61E − 01 | 6.24E − 03 | 9.48E − 01 | 8.65E − 01 | 7.30E − 06 |
24a | rs4478545 | 8 | A/G | PDP1 | ncRNA_intronic | 6.67E − 01 | 3.21E − 03 | 9.76E − 01 | 9.94E − 01 | 9.99E − 01 | 8.74E − 01 | 1.36E − 06 |
25 | rs10821132 | 9 | A/G | FAM120AOS | Intronic | 2.61E − 01 | 1.38E − 01 | 3.80E − 01 | 1.10E − 02 | 9.01E − 01 | 8.67E − 01 | 3.02E − 07 |
25 | rs10992790 | 9 | T/C | FAM120AOS | Intronic | 5.99E − 02 | 1.15E − 02 | 3.13E − 01 | 1.90E − 02 | 9.01E − 01 | 8.65E − 01 | 3.82E − 08 |
25 | rs2265576 | 9 | T/C | FAM120AOS | Intronic | 5.14E − 03 | 8.12E − 01 | 1.00E + 00 | 9.52E − 01 | NA | 1.00E + 00 | 3.73E − 07 |
26a | rs60018597 | 9 | T/C | TLR4 | Intergenic | 7.10E − 01 | 1.56E − 02 | 5.33E − 01 | 8.60E − 01 | 9.93E − 01 | 8.45E − 01 | 8.81E − 05 |
29 | rs1836799 | 11 | T/C | NCAM1 | Intronic | 2.04E − 01 | 7.22E − 01 | 1.39E − 02 | 2.29E − 02 | 9.01E − 01 | 9.96E − 01 | 3.84E − 05 |
29 | rs2155285 | 11 | A/G | NCAM1 | Intronic | 1.92E − 01 | 8.55E − 01 | 2.53E − 02 | 2.18E − 02 | 9.92E − 01 | 7.51E − 01 | 1.89E − 06 |
29 | rs4937872 | 11 | A/G | NCAM1 | Intergenic | 7.72E − 03 | 4.07E − 01 | 5.97E − 02 | 1.71E − 01 | 9.04E − 01 | 9.94E − 01 | 3.21E − 08 |
30 | rs1373277 | 13 | A/G | OLFM4 | Intergenic | NA | 2.04E − 02 | 6.11E − 03 | 9.85E − 01 | 9.01E − 01 | 8.12E − 01 | 1.18E − 05 |
30 | rs1909650 | 13 | A/G | OLFM4 | Intergenic | 7.62E − 01 | 1.19E − 04 | 1.18E − 01 | 6.62E − 01 | 9.01E − 01 | 8.01E − 01 | 1.53E − 07 |
32 | rs67505447 | 14 | A/G | LRFN5 | Intronic | 1.91E − 01 | 9.58E − 03 | NA | NA | NA | 1.00E + 00 | 4.29E − 05 |
33a | rs62083383 | 18 | A/G | DCC | Intronic | 3.87E − 02 | 7.98E − 01 | 9.19E − 01 | 1.00E + 00 | 9.10E − 01 | 9.53E − 01 | 1.57E − 04 |
34 | rs4801153 | 18 | T/C | TCF4 | Intronic | 2.70E − 01 | 3.37E − 02 | 1.00E + 00 | NA | NA | 7.43E − 01 | 2.86E − 04 |
36 | rs20551 | 22 | A/G | EP300 | Exonic | 7.18E − 01 | 3.91E − 04 | 3.24E − 01 | 7.38E − 04 | 9.67E − 01 | 5.93E − 01 | 6.16E − 07 |
37a | rs301805 | 1 | T/G | RERE | Intronic | 9.65E − 01 | 2.43E − 02 | 9.56E − 01 | 6.29E − 02 | 8.42E − 01 | 1.00E + 00 | 1.72E − 04 |
38a | rs11264103 | 1 | A/G | INPP5B | Upstream | 5.64E − 01 | 4.14E − 02 | 1.23E − 01 | 2.78E − 01 | 9.81E − 01 | 9.44E − 01 | 3.94E − 04 |
39 | rs10917847 | 1 | A/G | PBX1 | Intergenic | 8.42E − 01 | 1.47E − 01 | 1.47E − 03 | 1.97E − 03 | 1.00E + 00 | 8.76E − 01 | 1.88E − 06 |
40 | rs2175177 | 1 | A/G | COP1 | ncRNA_intronic | 9.80E − 01 | 9.54E − 04 | 1.82E − 01 | 8.20E − 01 | 8.37E − 01 | 9.83E − 01 | 1.84E − 06 |
42a | rs12713172 | 2 | T/C |  −  | ncRNA_intronic | 8.85E − 01 | 1.31E − 02 | 8.30E − 01 | 8.78E − 01 | 9.01E − 01 | 8.89E − 01 | 5.99E − 05 |
45a | rs332898 | 2 | T/G |  −  | Intergenic | 7.59E − 01 | 4.33E − 02 | 1.00E + 00 | 8.84E − 01 | 9.01E − 01 | 9.05E − 01 | 1.51E − 04 |
46a | rs66461219 | 2 | T/C | LRP1B | Intronic | 7.71E − 01 | 3.63E − 02 | 8.70E − 01 | 8.99E − 01 | 9.01E − 01 | 8.98E − 01 | 3.16E − 04 |
47a | rs12477286 | 2 | T/G | CIR1 | Intronic | 9.83E − 01 | 4.60E − 02 | 5.26E − 01 | 8.14E − 01 | 1.00E + 00 | 9.63E − 01 | 4.66E − 04 |
49a | rs12475098 | 2 | T/C | SLC4A3 | Intergenic | 8.49E − 01 | 3.21E − 02 | 7.82E − 01 | 7.43E − 01 | 9.57E − 01 | 9.07E − 01 | 2.64E − 04 |
52a | rs11945373 | 4 | A/G | DHX15 | Intergenic | 1.00E + 00 | 3.50E − 03 | 1.81E − 01 | 3.38E − 01 | 8.99E − 01 | NA | 1.03E − 05 |
53a | rs13143951 | 4 | A/C | NAA11 | ncRNA_intronic | 3.87E − 01 | 2.02E − 02 | 5.59E − 02 | 5.29E − 02 | 9.09E − 01 | 8.41E − 01 | 1.30E − 04 |
53a | rs9998799 | 4 | T/C | NAA11 | ncRNA_intronic | 3.37E − 01 | 2.21E − 02 | 3.77E − 02 | 5.75E − 02 | 9.05E − 01 | 8.07E − 01 | 1.49E − 04 |
54a | rs17344835 | 4 | T/C | BMPR1B | Intronic | 8.82E − 01 | 4.12E − 02 | 8.03E − 01 | 9.82E − 01 | 1.00E + 00 | 8.80E − 01 | 1.77E − 04 |
56a | rs72718909 | 4 | T/C | ZFP42 | Intergenic | 7.35E − 01 | 3.61E − 02 | 1.00E + 00 | 9.25E − 01 | 1.00E + 00 | 8.42E − 01 | 1.97E − 04 |
57 | rs10044618 | 5 | T/C | TMEM161B | ncRNA_intronic | 9.86E − 01 | 2.81E − 04 | 7.43E − 01 | 1.00E + 00 | 9.91E − 01 | 1.00E + 00 | 4.12E − 07 |
58a | rs7715167 | 5 | T/C | FGF18 | Intergenic | 8.05E − 01 | 6.48E − 01 | 4.43E − 01 | 3.62E − 02 | 9.32E − 01 | 8.62E − 01 | 2.02E − 05 |
59a | rs364659 | 6 | T/G | ASCC3 | Intergenic | 7.75E − 01 | 2.77E − 02 | 3.97E − 01 | 7.26E − 01 | 9.08E − 01 | 9.78E − 01 | 1.45E − 04 |
61 | rs17210284 | 7 | T/C | PCLO | Intronic | 6.64E − 01 | 4.97E − 03 | 3.10E − 03 | 5.09E − 02 | 9.01E − 01 | 8.65E − 01 | 4.78E − 06 |
61 | rs17371806 | 7 | A/G | PCLO | Intronic | 7.22E − 01 | 5.62E − 01 | 1.10E − 01 | 1.00E − 02 | 9.01E − 01 | 8.64E − 01 | 1.30E − 05 |
62a | rs10499973 | 7 | A/G |  −  | Intergenic | 3.53E − 01 | 3.59E − 02 | 7.80E − 01 | 2.51E − 01 | 6.69E − 01 | 1.00E + 00 | 3.14E − 04 |
65a | rs13296658 | 9 | A/C | ZDHHC21 | Intronic | 7.60E − 01 | 2.34E − 02 | 1.00E + 00 | NA | 9.01E − 01 | 8.75E − 01 | 4.23E − 05 |
67 | rs28481902 | 9 | T/C | TMEM38B | Intergenic | 7.62E − 01 | 8.41E − 01 | 4.93E − 02 | 1.70E − 01 | 9.38E − 01 | 8.65E − 01 | 7.56E − 05 |
70a | rs34062335 | 12 | T/C | SOX5 | Intronic | 8.36E − 01 | 4.92E − 02 | 8.32E − 01 | 7.78E − 01 | 9.02E − 01 | 1.00E + 00 | 5.04E − 04 |
73a | rs12914677 | 15 | T/G | LOXL1 | ncRNA_intronic | 8.47E − 01 | 7.17E − 01 | 3.53E − 02 | 8.72E − 01 | 9.97E − 01 | 8.74E − 01 | 1.65E − 04 |
74a | rs9928691 | 16 | A/G |  −  | Intergenic | 8.04E − 01 | 3.10E − 02 | 8.27E − 01 | 8.67E − 01 | 1.00E + 00 | 1.00E + 00 | 2.08E − 04 |
75a | rs77041900 | 16 | T/C | HAS3 | Intronic | 8.60E − 01 | 3.90E − 02 | 7.75E − 01 | 7.13E − 01 | NA | 8.67E − 01 | 2.80E − 04 |
76a | rs11643192 | 16 | A/C | HP | Intergenic | 9.96E − 01 | 4.13E − 02 | 6.00E − 02 | 5.67E − 01 | 9.65E − 01 | 8.64E − 01 | 3.92E − 04 |
79a | rs11650999 | 17 | A/G | MSI2 | Intronic | 8.79E − 01 | 2.78E − 02 | 9.98E − 01 | 9.15E − 01 | 1.00E + 00 | 9.77E − 01 | 1.35E − 04 |
80a | rs11877758 | 18 | T/G | CELF4 | Intronic | 4.68E − 01 | 3.46E − 02 | 1.00E + 00 | 7.16E − 01 | 8.31E − 01 | 1.00E + 00 | 2.97E − 04 |
81a | rs12965339 | 18 | A/C | DCC | Intronic | 5.72E − 01 | 3.34E − 02 | 7.87E − 01 | 7.31E − 01 | 5.91E − 01 | 9.45E − 01 | 2.82E − 04 |
84a | rs6130328 | 20 | A/G | PTPRT | Intergenic | 7.73E − 01 | 3.62E − 02 | 4.86E − 01 | 9.84E − 01 | 8.99E − 01 | 8.47E − 01 | 3.19E − 04 |
86a | rs7530647 | 1 | A/G | TRIT1 | Intronic | 7.87E − 01 | 6.73E − 01 | 3.91E − 01 | 9.99E − 01 | 4.32E − 02 | 8.57E − 01 | 7.16E − 06 |
87a | rs113445115 | 1 | T/C | UBAP2L | Intronic | 3.23E − 01 | 1.00E + 00 | 1.32E − 02 | 2.02E − 01 | 9.90E − 01 | 8.60E − 01 | 3.55E − 05 |
89a | rs72832204 | 2 | A/G | POU3F3 | ncRNA_intronic | 9.46E − 01 | 9.44E − 01 | 2.72E − 02 | 9.91E − 01 | 9.05E − 01 | 1.00E + 00 | 1.08E − 04 |
92a | rs1356292 | 3 | T/C | ETV5 | Intronic | 8.40E − 01 | 3.80E − 01 | 9.26E − 03 | 1.84E − 01 | 9.93E − 01 | 8.64E − 01 | 2.11E − 05 |
93a | rs13148166 | 4 | T/G | PPA2 | Downstream | 9.75E − 01 | 3.84E − 01 | 4.23E − 02 | 4.34E − 01 | 1.00E + 00 | 6.29E − 01 | 2.21E − 04 |
95a | rs174909 | 7 | T/G | WIPF3 | Intergenic | 8.47E − 01 | 8.38E − 01 | 3.19E − 02 | 4.03E − 01 | 9.66E − 01 | 9.87E − 01 | 1.40E − 04 |
96a | rs4909803 | 8 | T/G | FAM135B | Upstream | 8.26E − 01 | 1.52E − 01 | 3.28E − 02 | 1.04E − 01 | NA | 9.89E − 01 | 1.46E − 04 |
97a | rs1244445 | 10 | T/C | ITIH2 | Intergenic | 8.65E − 01 | 9.97E − 01 | 3.00E − 02 | 9.16E − 01 | 8.35E − 01 | 5.29E − 01 | 4.34E − 05 |
98a | rs10458677 | 10 | A/G | SLC16A9 | Intergenic | 9.88E − 01 | 8.21E − 01 | 4.19E − 02 | 5.28E − 01 | 1.00E + 00 | 9.27E − 01 | 1.80E − 04 |
101a | rs737237 | 11 | T/C | CNTN5 | Intronic | 5.26E − 01 | 1.61E − 01 | 3.89E − 02 | 2.39E − 01 | 9.67E − 01 | 8.78E − 01 | 1.92E − 04 |
102a | rs17711616 | 11 | A/G | ZC3H12C | ncRNA_intronic | 7.84E − 01 | 8.13E − 01 | 4.39E − 02 | 2.74E − 01 | 1.00E + 00 | 1.00E + 00 | 2.34E − 04 |
103a | rs6581887 | 12 | A/G | LYZ | Intergenic | 9.39E − 01 | 5.47E − 01 | 3.41E − 02 | 1.00E + 00 | 9.52E − 01 | 8.63E − 01 | 1.44E − 04 |
105a | rs11857990 | 15 | A/G | C15orf40 | ncRNA_intronic | 9.55E − 01 | 1.00E + 00 | 3.74E − 02 | 5.99E − 01 | 8.51E − 01 | 9.03E − 01 | 1.80E − 04 |
108a | rs917415 | 19 | A/C | GNG7 | UTR3 | 9.30E − 01 | 8.02E − 01 | 3.51E − 02 | 1.98E − 01 | 9.00E − 01 | NA | 1.63E − 04 |
109a | rs892086 | 19 | A/G | SLC44A2 | Intronic | 8.10E − 01 | 8.06E − 01 | 4.13E − 02 | 8.36E − 01 | 9.99E − 01 | 9.94E − 01 | 2.13E − 04 |
110a | rs2024568 | 20 | T/C | CD40 | Intergenic | 1.47E − 01 | 6.96E − 01 | 3.84E − 02 | 6.63E − 02 | 9.82E − 01 | 1.91E − 01 | 1.88E − 04 |
116a | rs73113782 | 3 | A/G |  −  | Intergenic | 8.49E − 01 | 8.06E − 01 | 5.72E − 01 | 4.85E − 02 | 1.00E + 00 | 9.59E − 01 | 1.08E − 04 |
117 | rs1280622 | 3 | A/C | PCCB | Intergenic | 7.32E − 01 | 8.58E − 01 | 8.20E − 01 | 3.14E − 03 | 7.97E − 01 | 8.75E − 01 | 3.24E − 06 |
118a | rs56387490 | 3 | T/C | LPP | Intronic | 1.00E + 00 | 8.37E − 01 | 3.99E − 01 | 4.51E − 02 | 1.00E + 00 | 9.33E − 01 | 8.28E − 05 |
123 | rs12277680 | 11 | A/G | B3GAT1 | Downstream | 5.23E − 01 | 7.93E − 01 | 1.00E + 00 | 2.60E − 02 | 8.96E − 01 | 9.88E − 01 | 4.57E − 05 |
127a | rs8703 | 17 | T/C | RABEP1 | UTR3 | 1.00E + 00 | 9.63E − 01 | 9.52E − 01 | 3.43E − 02 | 9.84E − 01 | 9.61E − 01 | 6.73E − 05 |