Fig. 5

Transcriptomic profiling reveals changes in inflammatory and extracellular remodelling pathways. Rag2^del mice were subjected to MI (denoted as MI) with or without cardiomyocyte transplantation (MI-CM), and 7 days after MI, the RNA from the heart and blood was isolated and analysed via a Clariom™ D microarray. A Analysis of the relative contribution of the various RNA categories of the upregulated and downregulated genes revealed a substantial contribution from non-coding RNAs (ncRNAs). Transcripts are considered differentially expressed (DE), if they show a twofold change and have a p-value < 0.05. B GO enrichment analysis expressed as % terms per group was performed on DE targets in the heart and blood. C Network analysis using the GO terms of these targets. In the network, the transcripts from the heart and the corresponding GO terms are represented in blue circles with the transcripts from the blood and their corresponding GO terms being represented in red circles. N = 3 in both groups