Fig. 3From: Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrenceIntercellular interaction analysis. A HCC-immune interaction analysis identified the activation of the PAX5 network. B, C HCC-CAF interaction analysis pointed to the activation of the FOS and JUN networks. D PAX5 is a transcription factor that regulates B cell activity, and the PAX5 network identified co-localizes with the distribution of B cells as determined by the spatial distribution of B cell markers. E FOS and JUN are transcription factors that can regulate genes involved in extracellular matrix remodeling, and the networks regulated by these genes colocalize with CAF marker genesBack to article page