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Fig. 6 | Genome Medicine

Fig. 6

From: Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence

Fig. 6

Cancer stem cell detection in hepatocellular carcinoma heterogeneous sample. A Cancer stem cell markers are highly expressed at the immune-poor tumor region of the responder sample with intrasample heterogeneity as noted by the spatial expression and the levels of expression are significantly different between the distinct tumor regions. B Heatmap with the expression of the CSC genes in the TCGA HCC samples. C Correlation heatmap with the Spearman correlation coefficient between expression of CSC markers and T cell proportions (CIBERSORT) in HCC samples from TCGA showing a negative correlation between T CD8 cell proportions and high expression of some CSC genes

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Genome Medicine

ISSN: 1756-994X

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