Fig. 2

PBMC genes associated with asthma. Differential gene expression analysis was performed. Genes associated with asthma in the discovery set (FDR \(\le\) 0.05) are shown in orange, and those that were also associated with asthma with the same direction of effect in the independent test set were deemed validated PBMC asthma genes. Key drivers identified and validated in downstream analyses are labeled, including key drivers of the NK cell-mediated cytotoxicity module (purple) and key drivers of the interleukin production module (blue)