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Table 1 Characteristics of the cohort

From: Integrated study of systemic and local airway transcriptomes in asthma reveals causal mediation of systemic effects by airway key drivers

 

All (N = 340)

Asthma

N = 200

No asthma

N = 141

p value

Age, mean (SD)

13.4 (4.8)

12.5 (4.6)

14.7 (5.0)

4.90E − 05

Sex female, no. (%)

164 (48%)

83 (42%)

81 (57%)

0.0042

Race/ethnicity, no. (%)

   

3.93E − 06

 Asian

23 (6.7%)

4 (2.0%)

19 (13.5%)

 

 Black

61 (17.9%)

43 (21.5%)

18 (12.8%)

 

 Latino

86 (25.2%)

63 (31.5%)

23 (16.3%)

 

 Multiple races or unknown

30 (8.8%)

15 (7.5%)

15 (10.6%)

 

 White

141 (41.3%)

75 (37.5%)

66 (46.8%)

 

aAsthma medications prescribed, no. (%)

 β-Agonist

190 (56.0%)

190 (95.0%)

0 (0%)

 

 ICS

44 (13.0%)

44 (22.0%)

0 (0%)

 

 ICS/long-acting β-antagonist

55 (16.1%)

55 (27.5%)

0 (0%)

 

 Leukotriene receptor antagonist

47 (13.8%)

47 (23.5%)

0 (0%)

 

 Omalizumab

5 (1.5%)

5 (2.5%)

0 (0%)

 

ACT score, mean (SD)

20.1 (5.3)

16.6 (4.2)

25 (0.0)

 < 2e − 16

FEV1% predicted, mean (SD)

88 (15.4)

86 (17.0)

90 (13.1)

0.022

FEV1/FVC ratio, mean (SD)

83.5 (10.9)

79.7 (10.3)

87.6 (10.0)

1.36E − 10

Allergen sensitization, no. (%)

261 (76.5%)

146 (73%)

115 (82%)

0.067

Hospitalizations for asthma in the past year, no. (%)

 0

174 (51%)

174 (87%)

NA

 

 1

11 (3.2%)

11 (5.5%)

NA

 

  ≥ 2

15 (4.4%)

15 (7.5%)

NA

 

Emergency dept visits for asthma in the past year, no. (%)

 0

132 (38.7%)

132 (66%)

NA

 

 1

20 (5.9%)

20 (10%)

NA

 

  ≥ 2

48 (14.1%)

48 (24%)

NA

 

Rhinosinusitis symptoms, no. (%)

111 (32.6%)

82 (41.0%)

29 (20.6%)

9.89e − 5

  1. P values were calculated using Fisher’s exact test for categorical variables and generalized linear regression for continuous variables
  2. ACT asthma control test, FEV1% force expiratory volume in 1 s, percent predicted, FEV1/FVC forced expiratory volume in 1 s/forced vital capacity
  3. aAsthma medications were held for at least 4 weeks before sampling