Table 1 Eligibility criteria for recruitment of index cases

An index case in a family that fulfils clinical criteria for a hereditary cancer syndrome

28 (14.4)

An index case with two primary cancers (either synchronous or metachronous) diagnosed at 60 years or younger

83 (42.6)

An index case with three primary cancers diagnosed at 70 years or younger

52 (26.7)

Index case with colorectal polyposis defined as per InSiGHT^a or eviQ^b testing guidelines for MUTYH and/or APC

29 (14.9)

A cancer-affected individual fulfilling two or more of the following criteria:

 • Early age at onset (under 40 years for adult cancer or < 10 years younger than the mean age of cancer diagnosis for that tumour type and sex^c)

 • One or more first-degree relatives with the same kind of cancer

 • Two or more first- or second-degree relatives with different cancers, where at least one cancer is very rare

42 (21.5)