Fig. 2

The IL-2-induced anti-inflammatory gene expression signature (IL2-AIS) score is progressively decreased after SARS-CoV-2 infection. A, B Decrease of IL2-AIS scores after the onset of symptoms in COVID-19 patients from the COMBAT cohort (A) or INCOV (B) cohorts. Each dot represents a clinical sample, and colours depict the different COVID-19 disease severity groups. In the INCOV cohort, patients are grouped by their worst recorded COVID-19 severity. The IL2-AIS score was calculated in T cells and CD8⁺ T cells in the COMBAT and INCOV cohorts, respectively. The variation in the IL2-AIS score from additional cell types are shown in Additional file 3: Fig. S2. IL2-AIS, anti-inflammatory gene expression signature induced by low-dose IL-2 immunotherapy. Dashed black lines represent locally weighted scatterplot smoothing (LOWESS) curves