Fig. 2

Chromosome-specific rates and age associations for putative meiotic- and mitotic-origin aneuploidies. A Chromosome-specific counts of putative meiotic (i.e., full copy number change; left panel) and putative mitotic (i.e., intermediate copy number change; right panel) whole-chromosome gains and losses observed in blastocysts (top panel) and arrested embryos (bottom panel) as determined with PGT-A. Only aneuploidies of entire autosomes are depicted, as distinguishing meiotic and mitotic origins of segmental aneuploidies and aneuploidies affecting sex chromosomes poses unique challenges (see the “Methods” section). B Observed rates of meiotic (left panel) and mitotic (right panel) aneuploidy in relation to maternal age, including both arrested embryos and blastocysts. Each data point represents a distinct IVF case. Lines represent predictions from binomial generalized linear models fit to the data, with standard errors of the predictions indicated in gray