Table 1 Incidence of various forms of aneuploidy in whole arrested embryos (see the “Methods” section for description of arrested embryos) versus trophectoderm biopsies of developing blastocysts as determined by preimplantation genetic testing for aneuploidy (PGT-A). Our approach for distinguishing putative meiotic and mitotic aneuploidies based on chromosome copy number results is detailed in the main text
From: Meiotic and mitotic aneuploidies drive arrest of in vitro fertilized human preimplantation embryos
Putative chromosome status | Abbreviation | Whole arrested embryos | Blastocyst-stage embryos (trophectoderm biopsies) |
|---|---|---|---|
Euploid | Euploid | 17 (6%) | 189 (31%) |
Meiotic whole-chromosome aneuploidy only | Meiotic only | 66 (22%) | 228 (37%) |
Meiotic whole-chromosome aneuploidy with mitotic whole-chromosome aneuploidy or segmental aneuploidy | Meiotic plus mitotic and/or seg | 141 (47%) | 119 (19%) |
Mitotic whole-chromosome aneuploidy only | Mitotic only | 32 (11%) | 29 (5%) |
Segmental aneuploidy with or without mitotic whole-chromosome aneuploidy | Mitotic and/or seg | 41 (14%) | 47 (8%) |
Total | 297 | 612 |