Fig. 1
From: Global analysis of suppressor mutations that rescue human genetic defects
A literature-curated suppression network. A A network of suppression interactions curated from the biomedical literature. Suppression interactions are represented as arrows that point from the suppressor to the query gene. Nodes are colored and grouped based on the function of the gene. Gray nodes indicate genes that are poorly characterized, multifunctional, or have functions that are not otherwise represented in the figure. B Proportional Venn diagram showing the number of unique suppression interactions that have been identified in cultured cells, in patients, or in both. C Degree distribution of suppression interactions. The number of unique suppression interactions is plotted against the number of query or suppressor genes showing that number of interactions. For clarity, interactions involving HBB and CFTR, which have a high interaction degree, are not shown in figure (A), but these interactions are included in figure (B) and (C)