Fig. 5

Suppressors of HBB and CFTR provide insight into disease pathology. A-B Suppressor genes that have been described for HBB (A) and CFTR (B). Nodes are colored and grouped based on the function of the genes. Gray nodes indicate genes that are poorly characterized, multifunctional, or that have functions that are not otherwise represented in the figure. Node size represents the number of times an interaction has been described. Nodes with a black border indicate suppressor genes that have been described in patients, nodes without a border represent suppressor genes that have been identified in cultured cells, and those with a dashed border have been found in both systems. C Distribution of HBB and CFTR suppression interactions across the mechanistic classes described in Fig. 4