Fig. 2
Manhattan plot (main-effect model). Results from GWAS of five CSF biomarker PC across both sexes. Each row represents a different PC as outcome. X-axis represents each chromosome and the y-axis the p-value of the SNP association with the outcome on a −log10 scale. All analyses were adjusted for sex, genetic ancestry, and SNP array. Red line indicates genome-wide significance threshold (p = 5 × 10−8). Yellow line indicates suggestive threshold (p = 1 × 10−6). Vertical lines point towards genome-wide significant loci based on any model. P-values below 1 × 10−10 were winsorized to 1 × 10−10