Fig. 3From: Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioningManhattan plot (sex stratified). Results from GWAS of five CSF biomarker PC for males and females separately. Each row represents a different PC as outcome. Per outcome, results for males are depicted at the bottom and for females at the top. X-axis represents each chromosome and the y-axis the p-value of the SNP association with the outcome on a −log10 scale. All analyses were adjusted for genetic ancestry and SNP array. Red line indicates genome-wide significance threshold (p = 5 × 10−8). Yellow line indicates suggestive threshold (p = 1 × 10−6). Vertical lines point towards genome-wide significant loci based on any model. P-values below 1 × 10−10 were winsorized to 1 × 10−10Back to article page