Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning

Table 1 PCA loadings. Component loadings of each biomarker (first column) on five principal components (column groups two to six) are displayed

Sample	Tau pathology/Degeneration (PC1)			Aβ Pathology (PC2)			Injury/Inflammation (PC3)			Non-AD Inflammation (PC4)			Non-AD Synaptic functioning (PC5)
Sample	Male (n = 601)	Female (n = 557)	All (n = 1158)	Male (n = 601)	Female (n = 557)	All (n = 1158)	Male (n = 601)	Female (n = 557)	All (n = 1158)	Male (n = 601)	Female (n = 557)	All (n = 1158)	Male (n = 601)	Female (n = 557)	All (n = 1158)
Tau	0.86	0.87	0.87	−0.05	−0.07	−0.06	0.23	0.25	0.23	0.26	0.24	0.24	0.27	0.27	0.27
pTau	0.91	0.89	0.91	−0.08	−0.07	−0.08	0.11	0.18	0.14	0.19	0.23	0.20	0.26	0.28	0.26
Aβ	−0.07	−0.07	−0.07	1.00	1.00	1.00	−0.03	−0.02	−0.03	−0.01	0.00	0.00	0.04	0.04	0.04
NfL	0.19	0.25	0.21	−0.04	−0.03	−0.03	0.95	0.93	0.94	0.25	0.27	0.25	0.08	0.10	0.08
YKL-40	0.31	0.33	0.32	−0.01	0.01	0.00	0.30	0.33	0.32	0.88	0.87	0.88	0.17	0.17	0.17
Ng	0.49	0.51	0.51	0.06	0.07	0.07	0.11	0.12	0.10	0.18	0.19	0.18	0.84	0.83	0.83
R²	0.33	0.33	0.33	0.17	0.17	0.17	0.18	0.18	0.18	0.16	0.16	0.16	0.15	0.15	0.15

ISSN: 1756-994X