Fig. 1

Heatmap showing the clustering of tumors based on the contribution of tumor mutational signatures SBS10a, SBS10b, SBS10d, SBS28, SBS14, SBS20 and “other signatures”. Analysis was performed with 64 tumor samples with somatic pathogenic variants in POLE and POLD1 EDs, 3 tumors belonging to three probands with germline pathogenic variants in POLD1, and 70 TCGA tumor samples without polymerase exonuclease domain variants