Loss of p53-DREAM-mediated repression of cell cycle genes as a driver of lymph node metastasis in head and neck cancer

Table 1 Gene expression studies that were included in meta-analyses to identify survival and lymph node metastasis-associated genes

First author /Study_label^a	Pubmed reference	Study accession^b	N genes^c	N patients survival (Censored\|Event, (% event))^d	N patients LNM (LNM0\|LNM + , (% LNM +))^e
TCGA	25631445	TCGA	18803	299\|220 (42)	176\|244 (58)
Wichmann [19]	26095926	GSE65858	15820	168\|85 (34)	77\|176 (70)
Walter [37]	23451093	GSE39366	12546	73\|64 (47)	51\|66 (56)
Fountzilas [38]	23950933	GSE27020	12265	75\|34 (31)	NA
Lohavanichbutr [39]	23319825	GSE41613	20408	46\|51 (53)	NA
Jung [40]	23757353	E-MTAB-1328	20408	48\|41 (46)	17\|63 (79)
Lohavanichbutr [39]	23319825	GSE42743	20408	32\|42 (57)	29\|45 (61)
Thurlow [41]	20458058	Thurlow	17079	43\|20 (32)	30\|34 (53)
Pickering [42]	23619168	GSE41116	17284	18\|24 (57)	16\|26 (62)
Bhosale [43]	28433800	GSE85195	19596	26\|5 (16)	22\|10 (31)
Chung_GSE3292 [44]	16943533	GSE3292	20408	24\|8 (25)	10\|21 (68)
García-Escudero [45]	29598951	GSE95805	18203	18\|13 (42)	25\|6 (19)
Chung_GSE2837 [46]	16912200	GSE2837	17473	14\|14 (50)	7\|21 (75)
Ambatipudi [47]	28433800	GSE23558	19596	18\|9 (33)	14\|13 (48)
Reis [48]	21989116	GSE31056	20408	14\|9 (39)	NA
Cromer [49]	14676830	GSE2379	8459	7\|13 (65)	NA
Pavón [50]	22696598	GSE23036	12265	NA	10\|53 (84)
Stansfield [51]	26884679	GSE33205	17284	NA	7\|37 (84)
Sticht [52]	18472963	GSE10121	10429	NA	12\|21 (64)
Enokida [53]	28977904	GSE78060	20408	NA	5\|21 (81)
Ye [54]	18254958	GSE9844	20408	NA	15\|11 (42)
O'Donnell [55]	15558013	GSE2280	12265	NA	8\|14 (64)
Kuriakose [56]	15170515	GSE6631	8459	NA	13\|9 (41)
Toruner [57]	15381369	GSE3524	12265	NA	7\|7 (50)

^aFirst author/Study_label: Study label consists of first author name combined with gene expression omnibus accession number for studies with the same first author’s name
^bStudy accession: Apart from TCGA, accessions represent gene expression omnibus accession numbers. Platform accession numbers are included for studies with multiple datasets generated using different platforms
^cN genes: Number of genes in dataset
^dNumber of patients with survival data including patients that were censored and that had an event, as well as the percentage of patient with events
^eNumber of patients with lymph node metastasis (LNM) data including patients that were LNM negative (LNM0) and positive (LNM +), as well as the percentage of LNM + patients

ISSN: 1756-994X