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Fig. 9 | Genome Medicine

Fig. 9

From: Early detection of hepatocellular carcinoma via no end-repair enzymatic methylation sequencing of cell-free DNA and pre-trained neural network

Fig. 9

The visualizations of attention weights in hyper- and hypo-DMRs. Panels A and D show the attention map of a hyper-DMR (chr2: 63,055,387–63055523) overlapping OTX1 and a hypo-DMR (“chr2: 104,265,134–104265334”) overlapping an Alu element. Darker colors represent higher attention weights. Panels B and E display the average weight of attention in each position of reads in hyper- and hypo-DMR. Red line denotes the reads from tumor tissues and green line indicates the reads from non-tumor cfDNA. Panels C and F show the frequency of each base in all reads from tumor tissues and non-tumor cfDNA. The methylated CpG sites were marked with letter “ML.” Larger letter represents higher frequency. Regions with high attention weights were marked with red rectangles

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Genome Medicine

ISSN: 1756-994X

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