Fig. 7

TME-cancer interactivity across HRD and HR-proficient cancer cells. a,b Number of significant ligand-receptor interactions established between cells in the a Qian et al. (48) and b Bassez et al. (49) cohorts according to CellphoneDB. Cancer cells are labelled as HRD if they have a positive HRD score, HR-proficient otherwise. The x-axis refers to cell types as sources, and the y-axis refers to cell types as targets. c,d The number of significant interactions between TME cell types as sources and cancer cells as targets, separated by HR status, across the c Qian et al. and d Bassez et al. cohorts. e Specific ligand-receptor interactions between T-cells and cancer cells, with cancer cells as the targets, across the Qian et al. and Bassez et al. cohorts. The red circles indicate interactions unique to HRD cells within a given cohort, and the yellow circles indicate interactions unique to HR-proficient cells within a given cohort. Grey circles represent common interactions