Table 1 Characteristics of pediatric MPAL patients analyzed in this study. Patient characteristics and clinical information with sex, age at disease diagnosis/relapse (Dx/Rel), white blood cell (WBC) count at Dx/Rel, peripheral blood blast percentage, bone marrow blast percentage, timepoint of sample collection, response to ALL-based induction therapy, relapsed/refractory disease, and patient status information. Response to ALL-based induction therapy is shown as minimal residual disease (MRD) positive (> 0.01%), MRD negative (< 0.01%), and induction failure (> 5%)
Characteristic | All MPAL (n = 9) | B/My MPAL (n = 4) | T/My MPAL (n = 5) |
|---|---|---|---|
Sex | |||
 Male | 7 (78%) | 3 (75%) | 4 (80%) |
 Female | 2 (22%) | 1 (25%) | 1 (20%) |
Age at presentation (years) | |||
 Mean (range) | 13.4 (8.7–15.8) | 14.6 (13.7–15.1) | 12.5 (8.7–15.8) |
  < 10 | 1 (11%) | 0 (0%) | 1 (20%) |
  ≥ 10 | 8 (89%) | 4 (100%) | 4 (80%) |
WBC at presentation (× 103/uL) | |||
 Mean (range) | 65.5 (7.1–180.1) | 56.1 (12.8–134.6) | 73 (7.1–180.1) |
  < 50 | 6 (67%) | 3 (75%) | 3 (60%) |
  ≥ 50 | 3 (33%) | 1 (25%) | 2 (40%) |
Peripheral blood blast % | |||
 Mean (range) | 59.5 (5.0–95.7) | 65.0 (31.8–95.7) | 54.0 (5.0–73.5) |
Bone marrow blast % | |||
 Mean (range) | 82.6 (40.2–97.7) | 92.4 (82.0–97.7) | 72.8 (40.2–96.4) |
Timepoint of sample collection | |||
 Initial diagnosis (Dx) | 8 (89%) | 4 (100%) | 4 (80%) |
 Relapse | 1 (11%) | 0 (0%) | 1 (20%) |
Response to ALL-based induction therapy (n = 7) | |||
 MRD negative | 2/7 (29%) | 1/4 (25%) | 1/3 (33%) |
 MRD positive | 3/7 (43%) | 2/4 (50%) | 1/3 (33%) |
 Induction failure | 2/7 (29%) | 1/4 (25%) | 1/3 (33%) |
Relapsed/refractory disease | |||
 Yes | 4 (44%) | 1 (25%) | 3 (60%) |
 No | 5 (56%) | 3 (75%) | 2 (40%) |
Patient status | |||
 Alive | 6/9 (67%) | 3 (75%) | 3 (60%) |
 Deceased | 3/9 (33%) | 1 (25%) | 2 (40%) |