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Fig. 6 | Genome Medicine

Fig. 6

From: Cancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine

Fig. 6

Mapping of the evolutionary clusters onto the anatomy of the prostate in GP5 and GP12. a In GP5, the anatomic mapping of non-metastatic and metastatic branches indicates multiple regions involved in metastatic spread. A star icon is shown at the approximate location of the most ancestral clones detected in the tumor, indicating the putative cancer anatomic origin. b In GP12, the mapping of the evolutionary clusters onto the anatomy of the prostate shows the path of growth and evolutionary advancement from the posterior left side of the mid-apex (denoted by a star icon) towards the base and seminal vesicles (SV). “No entry” icons indicate evolutionary branches and directions of tumor growth that are not present in any of the sampled metastases (SV or lymph nodes (LN))

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Genome Medicine

ISSN: 1756-994X

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