Fig. 5

Classification of schizophrenia individuals and prioritization of genes, SNPs, and regulatory network using genotype and gene expressions of four cell types (microglia and astrocytes, oligodendrocytes, inhibitory neurons, and excitatory neurons). A Balanced accuracies from 5-fold cross-validation of DeepGAMI dual-modality model (dark blue), DeepGAMI single modality model (orange) in comparison with Lasso (brown), LR (light blue), Random Forest (yellow), SVM (purple), MLP (pink), Varmole (red), and MOGONET (green). B Pathway enrichment of prioritized schizophrenia SNPs for four cell types. The blue shade gives the − log(p-values) of the term. C Prioritized cell-type gene regulatory networks with pink circles representing schizophrenia genes. The size of the target gene is defined by the number of prioritized links between the SNPs and the associated gene