Fig. 7
From: Annotation of cell types (ACT): a convenient web server for cell type annotation
Manual cell annotations with ACT are accurate and more sophisticated in basal cell carcinoma. A Comparison between original cell type labels and annotation results based on ACT. B The summary table of ACT indicated that the original dendritic cell was actually migratory dendritic cell. High expression of top-ranked upregulated genes, FSCN1 and LAMP3, in BCC is shown as evidence. C As shown in the summary table and interactive tree, the CD4+ T cell was a mixture of several similar cell types. Reclustering and annotation further confirmed this classification. Th17: T-helper 17 cell; Tfh: T follicular helper cell; CTL: Cytotoxic T cell; Tem: Effector memory CD8-positive, alpha-beta T cell; DC: Dendritic cell; mregDC: Migratory dendritic cell; Treg: Regulatory T cell; CD8_act_T_cells: CD8+ activated T cell; CD8_ex_T_cells: CD8+ exhausted T cell; pDC: Plasmacytoid dendritic cell; CAF: Cancer-associated fibroblast; Tcell_prolif: proliferating T cell